| 摘要 |
FIELD: medicine, pharmaceutics. ^ SUBSTANCE: invention refers to a method for preparing an anti-tuberculosis drug containing isoniaside and silver nanoparticles. The declared method consists in the fact that chitosan 1-5 wt %, isoniaside 6-10 wt % are successively dissolved in distilled water; the solution is heated up to 45-55C with added stabiliser specified in polyethylene glycol or gelatin, in the amount of 5-40 wt %, and the ingredients are mixed to dissolve them completely. Then ammonium citrate in the amount of 1 g per 1 l of the solution is added in mixing; a silver anode is electrochemically dissolved for 10-30 min at silver nanoparticle yield in the water solution of stabilisers 2-15 mg per 1 l, and isoniaside if it has not been added previously. ^ EFFECT: invention provides a high-effective preparation for treating tuberculosis wherein the preparation ingredients show a synergetic effect and reduce resistance of tuberculosis mycobacteria to various antibiotics. ^ 3 tbl, 1 dwg, 7 ex |
