NEW PROCESS FOR THE RESOLUTION OF ENANTIOMERS OF (3,4-DIMETHOXY-BICYCLO[4.2.0]OCTA-1,3-5-TRIEN-7-YL)NITRILE AND APPLICATION IN THE SYNTHESIS OF IVABRADINE

摘要

PROCESS FOR THE OPTICAL RESOLUTION OF THE COMPOUND OF FORMULA (I): BY CHIRAL CHROMATOGRAPHY. APPLICATION IN THE SYNTHESIS OF IVABRADINE, OF ITS ADDITION SALTS WITH A PHARMACEUTICALLY ACCEPTABLE ACID AND OF THEIR HYDRATES.