Cosmetic use of at least one thiophene compounds as an active agent for treating and/or preventing a cosmetic defect of skin and/or of its annexes linked to an imbalance in the differentiation and/or the proliferation of cells of epidermis

摘要

Cosmetic use of at least one thiophene compounds (I) and their salts, as an active agent for treating and/or preventing a cosmetic defect of the skin and/or of its annexes linked to an imbalance in the differentiation and/or the proliferation of cells of an epidermis, is claimed. Cosmetic use of at least one thiophene compounds of formula (I) and their salts, as an active agent for treating and/or preventing a cosmetic defect of the skin and/or of its annexes linked to an imbalance in the differentiation and/or the proliferation of cells of an epidermis, is claimed. n : 0 or 1; X : O or NH; either R1, R2 : H, -OH, -NH 2, F, 1-5C alkyl (optionally saturated and optionally interrupted by at least one heteroatoms of O, N or S), optionally saturated 5-10C cycloalkyl, or optionally saturated 5-10-membered ring comprising at least one heteroatoms of O, N or S; or R1R2 : optionally saturated 5-10 membered ring (optionally comprising at least one heteroatoms of O, N or S); R3 : H, -OH, -NH 2, F, optionally saturated 1-5C alkyl, optionally saturated 5-10C cycloalkyl, 5-10-membered ring (optionally saturated and comprising at least one heteroatom of O, N or S), -OR11, -R11OH, -C(O)R11, -OC(O)R11, -C(O)OR11, -C(O)NH 2, -C(O)NH-R11, -C(O)NHR11R12, or NR11R12; R11, R12 : 1-5C alkyl (optionally saturated and optionally interrupted by at least one heteroatoms of O, N or S); either R4 : H, -OH, -NH 2, F, optionally saturated 1-5C alkyl, -OR13, -R13OH, -C(O)R13, -OC(O)R13, -C(O)OR13, -C(O)NH 2, or -C(O)NH-R13; and R5 : H, -OH, -NH 2, F, optionally saturated 1-5C alkyl, -OR13, -R13OH, -C(O)R13, -OC(O)R13, -C(O)OR13, -C(O)NH 2, -C(O)NH-R13, or -(Y1) m-ZR14; or R4R5 : 3-8C cycloalkylene group; R13 : 1-5C alkyl group; and R6-R10 : H, -OH, -NH 2, fluorine, optionally saturated 1-5C alkyl, optionally saturated 5-10C cycloalkyl, -OR13, -R13OH, -C(O)R13, -OC(O)R13, -C(O)OR13, -C(O)NH 2, or -C(O)NH-R13. Independent claims are included for: (1) pharmaceutical or dermatological composition comprising (I) in a medium; (2) cosmetic composition comprising, (I) as active agent in a medium; and at least one cosmetic or dermatological ingredient comprising cosmetic or dermatological agent, preservatives, hydrophilic or lipophilic gelling agents, nonionic-, anionic-, and cationic surfactants, antioxidants, salts, perfumes, fillers, odor absorbers, dyestuffs, film-forming polymers, semi-crystalline polymers, gums, and/or volatile or nonvolatile oils; and (3) article for packaging a cosmetic-, pharmaceutical- or dermatological composition containing (I).. [Image] ACTIVITY : Dermatological; Vulnerary; Cytostatic; Antipsoriatic; Endocrine-Gen. MECHANISM OF ACTION : Skin-specific retroviral-like aspartic protease-filaggrin 2 complex modulator.