Cosmetic use of at least one thiophene compounds as an active agent for treating and/or preventing oily skin and/or skin associated cosmetic defects in an individual, where the defects are e.g. skin imperfections caused by hyperseborrhea

摘要

Cosmetic use of at least one thiophene compounds (I) and their salts as an active agent for treating and/or preventing oily skin and/or skin associated cosmetic defects, is claimed. Cosmetic use of at least one thiophene compounds of formula (I) and their salts as an active agent for treating and/or preventing oily skin and/or skin associated cosmetic defects, is claimed. n : 0 or 1; X : O or NH; either R1, R2 : H, -OH, -NH 2, F, 1-5C alkyl (optionally saturated and optionally interrupted by at least one heteroatoms of O, N or S), optionally saturated 5-10C cycloalkyl, or optionally saturated 5-10-membered ring comprising at least one heteroatoms of O, N or S; or R1R2 : optionally saturated 5-10 membered ring (optionally comprising at least one heteroatoms of O, N or S); R3 : H, -OH, -NH 2, F, optionally saturated 1-5C alkyl, optionally saturated 5-10C cycloalkyl, 5-10-membered ring (optionally saturated and comprising at least one heteroatom of O, N or S), -OR11, -R11OH, -C(O)R11, -OC(O)R11, -C(O)OR11, -C(O)NH 2, -C(O)NH-R11, -C(O)NHR11R12, or NR11R12; R11, R12 : 1-5C alkyl (optionally saturated and optionally interrupted by at least one heteroatoms of O, N or S); either R4 : H, -OH, -NH 2, F, optionally saturated 1-5C alkyl, -OR13, -R13OH, -C(O)R13, -OC(O)R13, -C(O)OR13, -C(O)NH 2, or -C(O)NH-R13; and R5 : H, -OH, -NH 2, F, optionally saturated 1-5C alkyl, -OR13, -R13OH, -C(O)R13, -OC(O)R13, -C(O)OR13, -C(O)NH 2, -C(O)NH-R13, or -(Y1) m-ZR14; or R4R5 : 3-8C cycloalkylene group; R13 : 1-5C alkyl group, preferably methyl or ethyl group; R14 : optionally saturated 5-10 membered ring (optionally comprising at least one heteroatoms of O, N or S); and R6-R10 : H, -OH, -NH 2, fluorine, optionally saturated 1-5C alkyl, optionally saturated 5-10C cycloalkyl, -OR13, -R13OH, -C(O)R13, -OC(O)R13, -C(O)OR13, -C(O)NH 2, or -C(O)NH-R13. An independent claim is included for pharmaceutical or dermatological composition comprising (I) in a medium. [Image] ACTIVITY : Antiseborrheic; Dermatological; Antipruritic. MECHANISM OF ACTION : Skin-specific retroviral-like aspartic protease-filaggrin 2 complex modulator.