发明名称 |
Factor VIII Variants and Methods of Use |
摘要 |
A Factor VIII fusion protein or a Factor VIII fusion heterodimer comprising Factor VIII in which an amino acid sequence of a modulator is present in the B-domain, or an amino acid sequence of a modulator replaces some or all of the amino acid sequence of the B-domain is disclosed. Nucleic acids encoding the inventive fusion proteins and fusion heterodimers are also disclosed, as are methods for producing the fusion proteins and fusion heterodimers, pharmaceutical compositions, and methods of treating deficiencies in coagulation with the inventive fusion molecules. |
申请公布号 |
US2012142593(A1) |
申请公布日期 |
2012.06.07 |
申请号 |
US201013260564 |
申请日期 |
2010.03.24 |
申请人 |
ZHAO XIAO-YAN;KRETSCHMER PETER JOHN;THOMPSON THOMAS EUGENE;SCHNEIDER DOUGLAS W.;MURPHY JOHN EDWARD;BAYER HEALTHCARE LLC |
发明人 |
ZHAO XIAO-YAN;KRETSCHMER PETER JOHN;THOMPSON THOMAS EUGENE;SCHNEIDER DOUGLAS W.;MURPHY JOHN EDWARD |
分类号 |
A61K38/37;A61P7/04;C07K19/00;C12N1/13;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/62;C12N15/63;C12P21/00 |
主分类号 |
A61K38/37 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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