发明名称 |
Modulating regulatory T cell activity via Interleukin 35 |
摘要 |
Methods for regulating T cell function in a subject, particularly regulatory T cell activity are provided. Methods of the invention include administering to a subject a therapeutically effective amount of an Interleukin 35 -specific binding agent, such as an antibody or small molecule inhibitor. The invention further provides methods for enhancing the immunogenicity of a vaccine or overcoming a suppressed immune response to a vaccine in a subject, including administering to the subject a therapeutically effective amount of an IL35-specific binding agent and administering to the subject a vaccine. In one embodiment the vaccine is a cancer vaccine. |
申请公布号 |
AU2007298571(B2) |
申请公布日期 |
2012.06.07 |
申请号 |
AU20070298571 |
申请日期 |
2007.09.24 |
申请人 |
ST. JUDE CHILDREN'S RESEARCH HOSPITAL |
发明人 |
WORKMAN, CREG;VIGNALI, DARIO;COLLISON, LAUREN;VIGNALI, KATE |
分类号 |
C07K14/52;A61K39/39;C07K14/54;C07K14/715 |
主分类号 |
C07K14/52 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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