The present invention relates to enhancing RNA expression in a cell such as a cell transfected with RNA by reducing the activity of RNA-dependent protein kinase (PKR). Thus, the present invention provides methods for expressing RNA in a cell comprising the step of reducing the activity of RNA-dependent protein kinase (PKR) in the cell. Reducing the activity of RNA-dependent protein kinase (PKR) in the cell increases the stability of RNA and/or increases the expression of RNA in the cell.
申请公布号
CA2819522(A1)
申请公布日期
2012.06.07
申请号
CA20112819522
申请日期
2011.12.02
申请人
BIONTECH AG;TRANSLATIONALE ONKOLOGIE AN DER UNIVERSITATSMEDIZIN DER JGU MAINZ GGMBH (TRON);UNIVERSITATSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITAT MAINZ