POLYPEPTIDE SCAFFOLD

摘要

A modified polypeptide is described comprising a whey acidic protein (WAP) domain, suitably a trappin WAP domain. The WAP domain is modified by insertion, deletion or substitution of at least one amino acid residue at a position in the WAP domain selected from the region between the first cysteine residue and the second cysteine residue (loop 1) in the polypeptide sequence and/or the region between the second cysteine residue and the third cysteine residue (loop 2) in the polypeptide sequence. Methods of generating the modified polypeptides and their use in pharmaceutical compositions are also described.