PYRAZOLE COMPOUND HAVING THERAPEUTIC EFFECT ON MULTIPLE MYELOMA

摘要

Provided is a novel therapeutic agent for myeloma. A pyrazole compound represented by general formula (1) (In the formula: R1 represents a C1-6 alkyl, an R17-substituted C1-6 alkyl, a C1-6 haloalkyl, a phenyl, or a phenyl substituted by a number (a) of R11, or the like; R2 represents a hydrogen atom, a C1-6 alkyl, a phenyl, or a phenyl optionally substituted by a number (e) of R21, or the like; R3 represents a hydrogen atom or the like; x represents a single bond or -(CR6R7)n-; R4 and R5 each independently represent a C1-6 alkyl or the like; R6 and R7 represent a hydrogen atom or a C1-6 alkyl; and R8 represents a phenyl, or a phenyl optionally substituted by a number (k) of R81, or the like.), a tautomer of the compound, or a pharmaceutically acceptable salt thereof, or a solvate thereof, and a therapeutic agent for multiple myeloma containing the aforementioned as an active ingredient.