发明名称 |
COMPOSITIONS AND METHODS FOR TREATING FOXP3+ TREG RELATED DISEASES |
摘要 |
Methods for treating or preventing a Foxp3+ T regulatory cell (Treg) related disease in a subject in need thereof comprise administering to the subject an effective amount of a pharmaceutical composition comprising an inhibitor of a histone/protein acetyltransferase (HAT). Methods for identifying an agent useful for treating or preventing a Foxp3+ T regulatory cell (Treg) related disease comprise (a) contacting a candidate agent with a test sample comprising Foxp3+ T regulatory cells (Tregs), and (b) comparing a function of the Foxp3+ Tregs in the test sample with that in a control sample, wherein inhibition of the function of the Foxp3+ Tregs in the test sample when compared with the control sample indicates that the candidate agent is an agent useful for treating or preventing a Foxp3+ Treg related disease. |
申请公布号 |
CA2819829(A1) |
申请公布日期 |
2012.06.07 |
申请号 |
CA20112819829 |
申请日期 |
2011.12.01 |
申请人 |
THE CHILDREN'S HOSPITAL OF PHILADELPHIA;THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA;THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE |
发明人 |
HANCOCK, WAYNE W.;ALBELDA, STEVEN M.;COLE, PHILIP A. |
分类号 |
A61K31/4155;A61P35/00 |
主分类号 |
A61K31/4155 |
代理机构 |
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代理人 |
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地址 |
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