| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide anti-connexin compounds and compositions useful for the treatment of various diseases, conditions and disorders in which modulation of connexins, hemichannels, and gap junctions would be benefit, and to provide methods for using these compounds and compositions as well as pharmaceutical formulations, kits, and medical devices. <P>SOLUTION: There are provided methods and compositions for modulating the activity of connexins, for example, for use for the treatment of cardiovascular, vascular, neurological, wounds and other indications. These compounds and methods can be used therapeutically, for example, to reduce the severity of adverse effects associated with diseases and disorders where localized disruption in direct cell-cell communication or prevention of hemichannel opening is desirable. In one aspect, compounds, compositions and methods for treating a subject with a vascular disorder are provided. <P>COPYRIGHT: (C)2012,JPO&INPIT |
