This disclosure provides platforms for delivery of herpes virus proteins to cells, particularly proteins that form complexes in vivo. In some embodiments these proteins and the complexes they form elicit potent neutralizing antibodies. Thus, presentation of herpes virus proteins using the disclosed platforms permits the generation of broad and potent immune responses useful for vaccine development.
申请公布号
WO2012051211(A3)
申请公布日期
2012.06.07
申请号
WO2011US55834
申请日期
2011.10.11
申请人
NOVARTIS AG;LILJA, ANDERS;LOOMIS, REBECCA;FRANTI, MICHAEL;MASON, PETER
发明人
LILJA, ANDERS;LOOMIS, REBECCA;FRANTI, MICHAEL;MASON, PETER