发明名称 |
4-SUBSTITUTED-CYCLOHEXYLAMINO-4-PIPERIDINYL-ACETAMIDE ANTAGONISTS OF CCR2 |
摘要 |
<p>The present invention comprises compounds of Formula (I). wherein: R1, R2, R3, R4, X, Y, and Z are as defined in the specification. The invention also comprises a method of preventing, treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is type II diabetes, obesity and asthma. The invention also comprises a method of inhibiting CCR2 activity in a mammal by administration of a therapeutically effective amount of at least one compound of Formula (I).</p> |
申请公布号 |
WO2012075115(A1) |
申请公布日期 |
2012.06.07 |
申请号 |
WO2011US62593 |
申请日期 |
2011.11.30 |
申请人 |
JANSSEN PHARMACEUTICA NV;LANTER, JAMES, C.;MARKOTAN, THOMAS, P.;SUBASINGHE, NALIN;SUI, ZHIHUA;ZHANG, XUQING |
发明人 |
LANTER, JAMES, C.;MARKOTAN, THOMAS, P.;SUBASINGHE, NALIN;SUI, ZHIHUA;ZHANG, XUQING |
分类号 |
C07D401/12;A61K31/404;A61K31/437;A61P3/00;A61P11/00;C07D471/04 |
主分类号 |
C07D401/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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