发明名称 |
DETECTION OF GENETIC OR MOLECULAR ABERRATIONS ASSOCIATED WITH CANCER |
摘要 |
Systems, apparatus, and methods are provided for determining genetic or molecular aberrations in a biological sample from an organism. Biological samples including cell-free DNA fragments are analyzed to identify imbalances in chromosomal regions, e.g., due to deletions and/or amplifications in a tumor. Multiple loci are used for each chromosomal region. Such imbalances can then be used to diagnose (screen) a patient for cancer, as well as prognosticate a patient with cancer, or to detect the presence or to monitor the progress of a premalignant condition in a patient. The severity of an imbalance as well as the number of regions exhibiting an imbalance can be used. A systematic analysis of non-overlapping segments of a genome can provide a general screening tool for a sample. Additionally, a patient can be tested over time to track severity of each of one or more chromosomal regions and a number of chromosomal regions to enable screening and prognosticating, as well as monitoring of progress (e.g. after treatment) |
申请公布号 |
CA2817370(A1) |
申请公布日期 |
2012.06.07 |
申请号 |
CA20112817370 |
申请日期 |
2011.11.30 |
申请人 |
THE CHINESE UNIVERSITY OF HONG KONG |
发明人 |
LO, YUK MING DENNIS;CHAN, KWAN CHEE;CHIU, WAI KWUN ROSSA;JIANG, PEIYONG |
分类号 |
C12Q1/68;G06F19/18;G06F19/20 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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