| 摘要 |
Un compuesto que tiene la fórmula (la) o una sal farmacéuticamente aceptable del mismo, en la que: Q1 es -N(R1)-; Q2 es -C(R3)-; Q3 es -C(R5)-; Q4 es -C(R9)-; R1 es -Ym(Ra), en el que -Ra es -H, -OH, -alquilo de C1-C8, -alquenilo de C2-C8, -alquinilo de C2-C8, -cicloalquilo de C3-C12, -fenilo, -naftilo, -heterociclo de 3 a 9 miembros, -OR14, -O(CH2)nOR14, -C(O)R14, -O-C(O)R14, -C(O)(CH2)n-R14, -O-C(O)OR14, -O-C(O)NHR14, -O-C(O)N(R14)2, -C(O)N(R14)2, -C(O)OR14, -C(O)NHR14, -S-R14, -SOR14, -S(O)2R14, -NHC(O)R14, -NHSR14, -NHSOR14, -NHS(O)2R14, -OS(O)2O-, O-C(S)R14, O-C(S)OR14, O-C(S)NHR14, O-C(S)N(R14)2, -C(S)OR14, -C(S)NHR14, -C(S)N(R14)2, -NHC(S)R14, -NR14C(S)R14, -NHC(S)NHR14, -NHC(S)N(R14)2, -NR14C(S)NHR14 o -NR14C(S)N(R14)2; R2 es -H, -alquilo de C1-C8 o -OH; R3 y R4 son independientemente -Ym(Rb), en el que -Rb es -H, halógeno, -NH2, -CN, -NO2, -SH, -N3, -alquilo de C1- C8, -O-(alquilo de C1-C8), -alquenilo de C2-C8, -alquinilo de C2-C8, -cicloalquilo de C3-C12, -fenilo, -naftilo, -heterociclo de 3 a 9 miembros, -OR14, -O(CH2)nOR14, -C(O)R14, -O-C(O)R14, -C(O)(CH2)n-R14, -O-C(O)OR14, -O-C(O)NHR14, -O-C(O)N(R14)2, -C(O)N(R14)2, -C(O)OR14, -C(O)NHR14, -S-R14, -SOR14, -S(O)2R14, -NHC(O)R14, -NHSR14, -NHSOR14, -NHS(O)2R14, O-C(S)R14, O-C(S)OR14, O-C(S)NHR14, O-C(S)N(R14)2, -C(S)OR14, -C(S)NHR14, -C(S)N(R14)2, -NHC(S)R14, -NR14C(S)R14, -NHC(S)NHR14, -NHC(S)N(R14)2, -NR14C(S)NHR14, -NR14C(S)N(R14)2, o R3 y R4, junto con el átomo de carbono al que están unidos, forman un anillo de 5 a 9 miembros; R5 es -alquilo de C1-C8 o -O-(alquilo de C1-C8); R6 es -H, halógeno, -OH, -NH2, -alquilo de C1-C8 ó -O-(alquilo de C1-C8); R7 es -Ym(Rc), en el que -Rc es -alquilo de C1-C8, -O-(alquilo de C1-C8) , -O-bencilo, -OH, -NH2, -NH(alquilo de C1-C5), -N(alquilo de C1-C5)2, -NH(fenilo), -N(fenilo)2, -NH(naftilo), -N(naftilo)2, -CN, -NO2, -N3, -alquinilo de C2-C8, -OR14, -O(CH2)nOR14, -C(O)R14, -O-C(O)R14, -C(O)(CH2)n-R14, -O-C(O)OR14, -O-C(O)NHR14, -O-C(O)N(R14)2, -C(O)N(R14)2, -C(O)OR14, -C(O)NHR14, -S-R14, -SOR14, -S(O)2R14, -NHC(O)R14, -NHSR14, -NHSOR14, -NHS(O)2R14, -O(CH2)nC(O)O(CH2)nCH3, O-C(S)R14, O-C(S)OR14, O-C(S)NHR14, O-C(S)N(R14)2, -C(S)OR14, -C(S)NHR14, -C(S)N(R14)2, -NHC(S)R14, -NR14C(S)R14, -NHC(S)NHR14, -NHC(S)N(R14)2, -NR14C(S)NHR14, -NR14C(S)N(R14)2; R8 es -Ym(Rd), en el que -Rd es -H, -OH, halógeno, amino, -NH(alquilo de C1-C5), -N(alquilo de C1-C5)2, -NH(fenilo), -N(fenilo)2, -NH(naftilo), -N(naftilo)2, -CN, -NO2, -N3, -alquilo de C1-C8, -(alquilo de C1-C8)-OH, -O-(alquilo de C1-C8), -alquenilo de C2-C8, -alquinilo de C2-C8, -cicloalquilo de C3-C12, -fenilo, -naftilo, -heterociclo de 3 a 9 miembros, -OR14, -O(CH2)nOR14, -C(O)R14, -O-C(O)R14, -C(O)(CH2)n-R14, -O-C(O)OR14, -O-C(O)NHR14, -O-C(O)N(R14)2, -C(O)N(R14)2, -C(O)OR14, -C(O)NHR14, -S-R14, -SOR14, -S(O)2R14, -NHC(O)R14, -NHSR14, -NHSOR14, -NHS(O)2R14, O-C(S)R14, O-C(S)OR14, O-C(S)NHR14, O-C(S)N(R14)2, -C(S)OR14, -C(S)NHR14, -C(S)n(R14)2, -NHC(S)R14, -NR14C(S)R14, -NHC(S)NHR14, -NHC(S)N(R14)2, -NR14C(S)NHR14, -NR14C(S)N(R14)2; R9, R10, R11, R12 y R13 son, independientemente, -Ym(Rc), en el que -Rc es H, halógeno, -NH2, alquilo de C1-C8, -NH(alquilo de C1-C5), -N(alquilo de C1-C5)2, -NH(fenilo), -N(fenilo)2, -NH(naftilo), -N(naftilo)2, -C(O)NH(alquilo de C1-C5), -C(O)N(alquilo de C1-C5), -NHC(O)(alquilo de C1-C5), -NHC(=NH2 +)NH2, -CN, -NO2, -N3, -heterociclo de 3 a 9 miembros, -OR14, -O(CH2)nOR14, -C(O)R14, -O-C(O)R14, -C(O)(CH2)n-R14, -O-C(O)OR14, -O-C(O)NHR14, -OC( O)N(R14)2, -C(O)N(R14)2, -C(O)OR14, -C(O)NHR14, -S-R14, -SOR14, -S(O)2R14, -NHC(O)R14, -NHSR14, -NHSOR14, -NHS(O)2R14, O-C(S)R14, O-C(S)OR14, O-C(S)NHR14, O-C(S)N(R14)2, -C(S)OR14, -C(S)NHR14, -C(S)N(R14)2, -NHC(S)R14, -NR14C(S)R14, -NHC(S)NHR14, -NHC(S)N(R14)2, -NR14C(S)NHR14, -NR14C(S)N(R14)2, o R11 y R12, junto con el átomo de carbono al que están unidos, forman un heterociclo de 5 a 9 miembros;
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