| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide methods for the treatment of an endobronchial infection in a patient by administering to the endobronchial system of the patient a dry powder aerosol composition comprising 90-130 mg of an aminoglycoside-based antibiotic one to three times a day for a first treatment period of 20-36 days. <P>SOLUTION: According to the embodiment of the invention, the first treatment period is followed by a second non-treatment period wherein no aminoglycoside antibiotic is administered to the endobronchial system of the patient. For the treatment of virulent infections, the cycle of the first treatment period of aminoglycoside treatment followed by the second non-treatment period wherein no aminoglycoside antibiotic is administered to the endobronchial system of the patient may be repeated two or more times until the desired antibacterial effect is obtained. In the case of chronic infections, such as infections occurring in cystic fibrosis patients, the first and second treatment periods may be repeated a multiplicity of times throughout the medical treatment of the patient. <P>COPYRIGHT: (C)2012,JPO&INPIT |
