Signature for the diagnosis of breast cancer aggressiveness and genetic instability
摘要
The present invention relates to a method for diagnosing aggressiveness and/or genetic instability of a breast cancer in a patient from a breast cancer sample of said patient, comprising: a) measuring in vitro the expression level of the POLQ gene and the expression level of a control gene in said patient breast cancer sample; b) calculating for said POLQ gene an expression level ratio of the expression level of POLQ to the expression of the said control gene in said patient breast cancer sample; c) comparing the said POLQ expression level ratio to a corresponding threshold value, and d) diagnosing breast cancer aggressiveness and genetic instability if the said POLQ expression level ratio is superior to a corresponding threshold values. Dedicated microarrays and kits are also described, as well as a method of selecting a suitable treatment.
申请公布号
AU2010317877(A1)
申请公布日期
2012.06.07
申请号
AU20100317877
申请日期
2010.11.12
申请人
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS);UNIVERSITE PAUL SABATIER TOULOUSE III;INSTITUT CLAUDIUS REGAUD
发明人
CAZAUX, CHRISTOPHE;HOFFMANN, JEAN-SEBASTIEN;BOURDON, JEAN-CHRISTOPHE;MACHADO DA SILVA, ALICE;ROCHE, HENRI