| 摘要 |
<P>PROBLEM TO BE SOLVED: To bring advantages on the therapy of patients having related diseases by inhibiting the activity of tyrosine kinase. <P>SOLUTION: There are provided: compounds that form covalent bonds with Bruton's tyrosine kinase (Btk); irreversible inhibitors of Btk; methods for the preparation of the compounds; pharmaceutical compositions that include the compounds; and also methods of using the Btk inhibitors, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions. <P>COPYRIGHT: (C)2012,JPO&INPIT |
