发明名称 |
HYBRID CYCLIC LIBRARIES AND SCREENS THEREOF |
摘要 |
Provided are novel types of hybrid cyclic libraries that contain a known protein binding domain of a natural product. Also provided are synthetic methods to make such libraries and methods for the deconvolution of hits using partially split-pooled library compounds. Such methods are applicable for use with the entire human proteome to screen such libraries that bind and for the identification of hits. |
申请公布号 |
WO2012075048(A2) |
申请公布日期 |
2012.06.07 |
申请号 |
WO2011US62471 |
申请日期 |
2011.11.29 |
申请人 |
THE JOHNS HOPKINS UNIVERSITY;LIU, JUN, O. |
发明人 |
LIU, JUN, O. |
分类号 |
C07D471/04;A61K31/4353;A61K31/436;C07D498/04;C07D498/14;C07D515/04 |
主分类号 |
C07D471/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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