| 摘要 |
Described herein is a method of detecting an analyte comprising providing a capture electrode comprising probe molecules at the surface thereof, wherein the probe molecules are designed to specifically bind to said analyte, contacting the capture electrode with a sample solution, such that said analyte in the solution forms a probe-analyte complex at the surface of said capture electrode, and measuring the electrical properties of the capture electrode after contact with said sample solution, wherein changes in said electrical properties are indicative of the formation of the probe-analyte complex at the electrode surface. The measuring is conducted in measuring solutions comprising solvents having high dielectric constants, or measuring solutions having high pH, or with electrode surfaces having been contacted with solutions comprising organic solvents. |
