NUCLEIC ACID COMPOUNDS FOR INHIBITING HRAS GENE EXPRESSION AND USES THEREOF

摘要

This disclosure provides double- stranded nucleic acid complexes having one or more hydroxymethyl substituted nucleomonomer(s) and wherein one strand is complementary to a HRAS mRNA. Nucleic acid complexes of the disclosure may be useful for therapeutic applications, diagnostic applications or research applications. Nucleic complexes include short interfering RNA complexes (siRNA) capable of modulating gene expression comprising an antisense strand and a continuous or a discontinuous passenger strand ("sense strand"). Further, one or more hydroxymethyl substituted nucleomonomer(s) of this disclosure may be positioned at the 3 '-end, at the 5 '-end, at both the 3 '-end and 5 'end, and/or in a double-stranded region of a nucleic acid complex. Also provided are methods of decreasing expression of a HRAS gene in a cell or in a subject to treat a HRAS-related disease.