发明名称 |
METODO DI SINTESI DELL'ACIDO GLICOCOLICO. |
摘要 |
<p>Process for preparing glycocholic acid comprising the following steps: a) making a mixed anhydride of cholic acid through the suspension of cholic acid in acetone or in aqueous acetone in presence of a base, and subsequent reaction with an alkyl chloroformate; b) aminolysis of the so obtained mixed anhydride of cholic acid with an aqueous solution of a glycine ester, resulting in an ester of glycocholic acid; c) hydrolysis of the ester of glycocholic acid thus obtained through the treatment with aqueous soda or aqueous potassium and precipitation of glycocholic acid through acidification of the corresponding sodium salt.</p> |
申请公布号 |
IT1394296(B1) |
申请公布日期 |
2012.06.06 |
申请号 |
IT2009MI00782 |
申请日期 |
2009.05.08 |
申请人 |
PRODOTTI CHIMICI E ALIMENTARI SPA |
发明人 |
ZUCCOTTI PIERFRANCA;GALDI GIANLUCA;PARENTI MASSIMO |
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