HUMAN ANTIBODIES TO HUMAN DELTA LIKE LIGAND 4

摘要

An isolated human antibody or a fragment of a human antibody which specifically binds to human delta-like ligand 4 (hDII4) and blocks hDII4 binding to a Notch receptor. The human anti-hDII4 antibody or antibody fragment binds hDll4 with an affinity of ‰¤ 500 pM, as measured by surface plasmon resonance.