发明名称 |
ANTIGENE LOCKS AND THERAPEUTIC USES THEREOF |
摘要 |
An oligonucleotide based therapeutic strategy, called anti-gene locks, is described which specifically kills cells based on their genotype. The strategy employs oligonucleotides with arms and a backbone that are complementary to both strands of the gene target. Anti-gene locks bind in vitro in a sequence dependent fashion and inhibit DNA synthesis. In bacterial cells containing an episome target, they cause elimination of the extra-chromosomal DNA structure. When the target is present in the bacterial or human genome, they selectively kill the majority of these cells. |
申请公布号 |
US2012135521(A1) |
申请公布日期 |
2012.05.31 |
申请号 |
US201113247366 |
申请日期 |
2011.09.28 |
申请人 |
ESHLEMAN JAMES R.;PARKER ANTONY R. |
发明人 |
ESHLEMAN JAMES R.;PARKER ANTONY R. |
分类号 |
C12N5/02;A61K38/00;C07H21/04;C12N15/113 |
主分类号 |
C12N5/02 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|