发明名称 |
MICROFLUIDIC DEVICE FOR PHARMACOKINETIC-PHARMACODYNAMIC STUDY OF DRUGS AND USES THEREOF |
摘要 |
A microfluidic device for culturing cells, termed a microscale cell culture analog (μCCA), is provided. The microfluidic device allows multiple cell or tissue types to be cultured in a physiologically relevant environment, facilitates high-throughput operation and can be used for drug discovery. The microfluidic device uses gravity-induced fluidic flow, eliminating the need for a pump and preventing formation of air bubbles. Reciprocating motion between a pair of connected reservoirs is used to effect the gravity-induced flow in microfluidic channels. Bacterial contamination is reduced and high throughput enabled by eliminating a pump. The microfluidic device integrates a pharmacokinetic-pharmacodynamic (PK-PD) model to enable PK-PD analyses on-chip. This combined in vitro/in silico system enables prediction of drug toxicity in a more realistic manner than conventional in vitro systems.
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申请公布号 |
US2012135452(A1) |
申请公布日期 |
2012.05.31 |
申请号 |
US201013387585 |
申请日期 |
2010.07.29 |
申请人 |
SHULER MICHAEL L.;SUNG JONG HWAN;CORNELL UNIVERSITY |
发明人 |
SHULER MICHAEL L.;SUNG JONG HWAN |
分类号 |
C12Q1/02;C12M1/00;C12N5/02 |
主分类号 |
C12Q1/02 |
代理机构 |
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地址 |
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