发明名称 |
Peritoneal dialysis methods and apparatus |
摘要 |
A peritoneal-based ("bloodless") artificial kidney processes peritoneal fluid without need for additional fluids ("waterless"). Fluid is separated into a protein-rich stream and a protein-free stream. The protein-rich stream is regenerated using a sorbent assembly, and its protein composition can be modified by removal of selected protein(s) ("dialysate-pheresis"). It is then reconstituted with additives and returned into the peritoneal cavity, thereby reducing protein-loss and providing oncotic-pressure for ultrafiltration. The protein-free stream is used to produce free water, and an alkaline or acid fluid for optimization of the composition of the regenerated stream. The unused protein-free stream can be used to "reverse flush" the separator to maintain its patency and the excess discarded for fluid-balance regulation. Compared to prior art, immobilization of urease allows more protein rich fluid to be regenerated and re-circulated into the peritoneal cavity for toxin removal and allows practicable development of portable and wearable artificial kidneys. |
申请公布号 |
AU2007211317(B2) |
申请公布日期 |
2012.05.31 |
申请号 |
AU20070211317 |
申请日期 |
2007.01.30 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;U.S. GOVERNMENT: DEPARTMENT OF VETERANS AFFAIRS |
发明人 |
ROBERTS, MARTIN;LEE, DAVID B.N. |
分类号 |
A61M1/00 |
主分类号 |
A61M1/00 |
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