| 发明名称 |
ANTI-INFLAMMATORY COMPOUNDS AND USES THEREOF |
| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide anti-inflammatory compounds, pharmaceutical compositions thereof, and methods of use thereof for treating inflammatory disorders, as well as to provide a method of inhibiting NF-κB-dependent target gene expression in a cell. <P>SOLUTION: The invention relates to a method of inhibiting activation of NF-κB transported by cytokine by blocking the interaction of NEMO with IκB-kinase-β (IKKβ) with NEMO binding domain (NBD). <P>COPYRIGHT: (C)2012,JPO&INPIT |
| 申请公布号 |
JP2012100663(A) |
申请公布日期 |
2012.05.31 |
| 申请号 |
JP20110270736 |
申请日期 |
2011.12.09 |
| 申请人 |
YALE UNIV |
发明人 |
MAY MICHAEL J;GHOSH SANKAR |
| 分类号 |
A61K38/00;C12N15/09;A61K45/00;A61P1/04;A61P7/02;A61P9/10;A61P9/14;A61P11/00;A61P11/02;A61P11/06;A61P13/12;A61P17/00;A61P17/02;A61P17/04;A61P17/06;A61P19/02;A61P19/10;A61P21/00;A61P25/00;A61P25/28;A61P27/02;A61P29/00;A61P31/04;A61P31/06;A61P31/08;A61P31/12;A61P35/00;A61P37/02;A61P37/06;A61P37/08;A61P43/00;C07K7/06;C07K7/08;C07K14/47;C07K19/00;C12N5/071;C12N9/12;C12Q1/02 |
主分类号 |
A61K38/00 |
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