Adsorptive media for chromatography, particularly ion-exchange chromatography, derived from a shaped fiber. In certain embodiments, the functionalized shaped fiber presents a fibrillated or ridged structure which greatly increases the surface area of the fibers when compared to ordinary fibers. Also disclosed herein is a method to add surface pendant functional groups that provides cation-exchange or anion-exchange functionality to the high surface area fibers. This pendant functionality is useful for the ion-exchange chromatographic purification of biomolecules, such as monoclonal antibodies (mAbs).
申请公布号
WO2012015908(A3)
申请公布日期
2012.05.31
申请号
WO2011US45519
申请日期
2011.07.27
申请人
EMD MILLIPORE CORPORATION;YAVORSKY, DAVID;AMARA, JOHN;UMANA, JOAQUIN;CATALDO, WILLIAM;KOZLOV, MIKHAIL;STONE, MATTHEW
发明人
YAVORSKY, DAVID;AMARA, JOHN;UMANA, JOAQUIN;CATALDO, WILLIAM;KOZLOV, MIKHAIL;STONE, MATTHEW