| 发明名称 |
UTILIZATION OF PHARMACOLOGICAL CHAPERONES TO IMPROVE MANUFACTURING AND PURIFICATION OF BIOLOGICS |
| 摘要 |
The present invention provides methods for improving the production of recombinant proteins through the use of pharmacological chaperones for the recombinant proteins. As exemplified by the present invention, the binding of a pharmacological chaperone to a recombinant protein expressed by a cell can stabilize the protein and increase export of the protein out of the cell's endoplasmic reticulum, and increase secretion of the protein by the cell. |
| 申请公布号 |
WO2012071451(A2) |
申请公布日期 |
2012.05.31 |
| 申请号 |
WO2011US61916 |
申请日期 |
2011.11.22 |
| 申请人 |
AMICUS THERAPEUTICS, INC.;DO, HUNG, V. |
发明人 |
DO, HUNG, V. |
| 分类号 |
C12N9/26;C12N9/42 |
主分类号 |
C12N9/26 |
| 代理机构 |
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