PHARMACEUTICAL COMPOSITION FOR SUPPRESSING ANGIOGENESIS, AND METHOD FOR SCREENING ACTIVE MATERIAL FOR SUPPRESSING ANGIOGENESIS

摘要

The present invention provides a pharmaceutical composition for suppressing angiogenesis, containing heat shock protein 27 (HSP27) or a nucleic acid encoding HSP27. In addition, the present invention provides a pharmaceutical composition for treating cancer, containing HSP27 or a nucleic acid encoding HSP27. Additionally, the present invention provides a method for suppressing the in vitro growth of endothelial cells using HSP27. Further, the present invention provides a method for screening an active material for suppressing angiogenesis or an active material for treating cancer, comprising the following steps: processing endothelial cell lines into samples, respectively; measuring the content of HSP27 in an endothelial cell line; and selecting the sample in which the content of HSP27 in an endothelial cell line is increased compared with a control group.