发明名称 |
METHOD FOR DIFFERENTIATION OF STEM CELLS INTO VASCULAR CELLS AND THE INDUCTION OF ANGIOGENESIS USING THE SAME |
摘要 |
The present invention relates to a method for differentiating stem cells into vascular cells by culturing them in the form of a three-dimensional cell cluster and the use of the three-dimensional cell cluster for angiogenesis. Specifically, the present invention teaches a method for differentiating stem cells into vascular cells comprising culturing stem cells by adhering them onto a culture plate with a surface having a hydrophobic property or a culture plate onto which a growth factor is immobilized, wherein the cultured stem cells are later detached from the culture plate as their density increases to form a three-dimensional cell cluster and grown in the form of a three-dimensional cell cluster while differentiating into vascular cells. Also disclosed is the use of a three-dimensional cell cluster composed of the vascular cells differentiated from stem cells by the above method as a cell therapy agent for angiogenesis.
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申请公布号 |
US2012134965(A1) |
申请公布日期 |
2012.05.31 |
申请号 |
US201013259767 |
申请日期 |
2010.03.24 |
申请人 |
KIM SANG-HEON;KIM SOO HYUN;PARK IN SU;JUNG YOUNG MEE |
发明人 |
KIM SANG-HEON;KIM SOO HYUN;PARK IN SU;JUNG YOUNG MEE |
分类号 |
A61K35/12;A61P9/00;A61P9/04;A61P9/10;A61P9/12;A61P25/00;C12N5/071;C12N5/077;C12N5/0775;C12N5/0789;C12N5/0797 |
主分类号 |
A61K35/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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