发明名称 |
HUMAN MATRIX METALLOPROTEINASE-8 GENE DELIVERY ENHANCES THE ONCOLYTIC ACTIVITY OF A REPLICATING ADENOVIRUS |
摘要 |
The present invention discloses a method of treating cancer in a subject. This involves co-administering a replicating virus and a matrix metalloproteinase to the subject under conditions effective to treat cancer. It also relates to a method of enhancing the delivery to and distribution within a tumor mass of therapeutic viruses. This involves co-administering a replicating virus and a matrix metalloproteinase to the tumor mass under conditions effective to enhance the delivery to and distribution within the tumor mass of therapeutic viruses. Another aspect relates to a cancer therapeutic. This involves a replicating virus and a matrix metalloproteinase.
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申请公布号 |
US2012134964(A1) |
申请公布日期 |
2012.05.31 |
申请号 |
US201113336424 |
申请日期 |
2011.12.23 |
申请人 |
HAY JOHN G.;CHENG JIN;SAUTHOFF HARALD;NEW YORK UNIVERSITY |
发明人 |
HAY JOHN G.;CHENG JIN;SAUTHOFF HARALD |
分类号 |
A61K38/48;A61P35/00 |
主分类号 |
A61K38/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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