PROCESS FOR SEPARATING MALIGN AND BENIGN TUMORS EX VIVO THROUGH THE USE OF DCE-MRI AND/OR DSC-MRI

摘要

It is disclosed a process and a computer-based program for distinguishing ex vivo between benign and malign tumors in tissues such as soft tissues and particularly breast tissue through the registration and comparison of measurement data from dynamic contrast-enhanced magnetic resonance imagining (DCE-MRI) and dynamic susceptibility contrast-enhanced magnetic resonance (DSC) imagining of the tumors. The process and the computer-based program is adjusted to initially performing two dynamic MRI pulse sequences in an interleaved mode during parenteral administration of an MR contrast substance, wherein one of said pulse sequences is optimized for high spatial resolution and the other pulse sequence is adjusted for high temporal resolution, the high-temporal dissolved sequence further comprising a double echo-collection being sensitive towards both DCE and DSC for generating a number of different biomarker data such as pharmacokinetic biomarker data, descriptive DCE biomarkers and descriptive DSC biomarkers, and subsequently normalizing and comparing said data with corresponding data from corresponding benign and malign tumors, respectively. From each tumor volume there is preferably collected biomarkers for the 95-percentile identifying most of the abnormal kinetic properties (belonging to the relevant biomarker).