SOLID STATE FORMS OF SORAFENIB BESYLATE, AND PROCESSES FOR PREPARATIONS THEREOF

摘要

The application discloses novel solid state forms, referred to herein as Forms IV, V and VI, of Sorafenib Besylate; processes for preparing them; and pharmaceutical compositions and formulations comprising these forms. The invention further encompasses the above described solid state forms of Sorafenib Besylate for use in the preparation of other salts of Sorafenib, solid state forms thereof and pharmaceutical formulations containing them, and for use in the treatment of cancers, particularly, renal and hepatocellular cancer.