发明名称 |
Di(µ-S)-bis{chloro-[phenyl(pyridine-2-yl)methanone-thiosemicarbazonato(1-)]-copper} manifesting the property of inhibiting the proliferation of mammary cancer T-47D cells |
摘要 |
The invention relates to chemistry and medicine, namely to a biologically active complex combination of copper with thiosemicarbazone, which can be used in medicine as a cytostatic preparation in the prevention and treatment of mammary cancer.Summary of the invention consists in the synthesis of a new coordinative compound of copper with 2-benzoylpyridine thiosemicarbazone, di(µ-S)-bis{chloro-[phenyl(pyridine-2-yl)methanone-thiosemicarbazonato(1-)]-copper} of formula:manifesting the property of inhibiting the proliferation of mammary cancer T-47D cells.The technical result is to increase the range of coordinative compounds with anticancer activity, which at a concentration of 10-6 mol/L is about 4 times higher than the similar characteristics of the closest analogue from the class of copper thiosemicarbazonates. |
申请公布号 |
MD4132(C1) |
申请公布日期 |
2012.05.31 |
申请号 |
MD20100000137 |
申请日期 |
2010.12.13 |
申请人 |
UNIVERSITATEA DE STAT DIN MOLDOVA |
发明人 |
GULEA AURELIAN;TAPCOV VICTOR;STRAISTARI TATIANA;POIRIER DONALD;&TCEDIL,APCOV VICTOR |
分类号 |
C07C337/08;A61K31/175;A61K31/30;A61P35/00;A61P35/04;C07C49/303;C07D213/50;C07F1/08 |
主分类号 |
C07C337/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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