| 发明名称 |
CARBOXYLIC ACID DERIVATIVES THAT INHIBIT THE BINDING OF INTEGRINS TO,THEIR RECEPTORS |
| 摘要 |
<p>A method for the inhibition of the binding of alpha4beta1 integrin to its receptors, for example VCAM-1 (vascular cell adhesion molecule-1) and fibronectin; compounds that inhibit this binding; pharmaceutically active compositions comprising such compounds; and to the use of such compounds either as above, or in formulations for the control or prevention of diseases states in which alpha4beta1 is involved.</p> |
| 申请公布号 |
SI21096(B) |
申请公布日期 |
2012.05.31 |
| 申请号 |
SI20010000288 |
申请日期 |
2001.11.05 |
| 申请人 |
ENCYSIVE PHARMACEUTICALS, INC. |
发明人 |
BIEDIGER RONALD J.;CHEN QI;HOLLAND GEORGE W.;KASSIR JAMAL M.;LI WEN;MARKET ROBERT V.;SCOTT IAN L.;WU CHENGDE |
| 分类号 |
C07D221/04;A61K31/435;A61K31/44;A61K31/4412;A61K31/4704;A61K31/495;A61K31/50;A61K31/505;A61P1/00;A61P3/10;A61P9/10;A61P11/06;A61P19/02;A61P25/00;A61P29/00;A61P35/00;A61P35/02;A61P37/02;A61P37/08;C07D207/416;C07D211/86;C07D213/02;C07D213/62;C07D213/69;C07D213/72;C07D213/75;C07D215/22;C07D215/38;C07D221/16;C07D237/16;C07D237/22;C07D239/28;C07D239/46;C07D239/47;C07D317/46;C07D317/60;C07D401/04;C07D401/12;C07D403/12;C07D405/12;C07D409/06;C07D409/12;C07D409/14;C07D413/04;C07D413/06;C07D413/12;C07D417/06;C07D471/04;C07D498/04;C07K14/78 |
主分类号 |
C07D221/04 |
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