发明名称 |
Amphoteric Liposomes, A Method Of Formulating An Amphoteric Liposome And A Method Of Loading An Amphoteric Liposome |
摘要 |
An amphoteric liposome composed of a mixture of lipids, said mixture comprising a cationic amphiphile, an anionic amphiphile and optionally one or more neutral amphiphiles, at least one of said cationic and anionic amphiphiles being chargeable and the respective amounts of said cationic and anionic amphiphiles being selected such there is a stoichiometric excess of positively charged cationic amphiphile at a first lower pH, a stoichiometric excess of negatively charged anionic amphiphile at a second higher pH and said mixture has an isoelectric point intermediate said first and second pHs; characterised in that said positively charged cationic and negatively charged anionic amphiphiles are adapted to form a lipid salt with one another at said isoelectric point. Also disclosed are methods of predicting the fusogenicity of an amphoteric liposome at a given pH, formulating an amphoteric liposome and loading an amphoteric liposome with a cargo moiety. |
申请公布号 |
US2012135065(A1) |
申请公布日期 |
2012.05.31 |
申请号 |
US201213350137 |
申请日期 |
2012.01.13 |
申请人 |
PANZNER STEFFEN;LUTZ SILKE;SIEPI EVGENIOS;MUELLER CLAUDIA;MARINA BIOTECH, INC. |
发明人 |
PANZNER STEFFEN;LUTZ SILKE;SIEPI EVGENIOS;MUELLER CLAUDIA |
分类号 |
A61K9/127;A61K31/7088;A61K47/44;C07J43/00 |
主分类号 |
A61K9/127 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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