| 发明名称 |
POLYCYCLIC INDAZOLE DERIVATIVES AND THEIR USE AS ERK INHIBITORS FOR THE TREATMENT OF CANCER |
| 摘要 |
Disclosed are the ERK inhibitors of formula 1.0: (Chemical formula should be inserted here as it appears on abstract in paper form) and the pharmaceutically acceptable salts, esters and solvates thereof. Q is a piperidine or piperazine ring that can have a bridge or a fused ring. The piperidine ring can have a double bond in the ring. All other substitutents are as defined herein. Also disclosed are methods of treating cancer using the compounds of formula 1.0. |
| 申请公布号 |
ZA200908477(B) |
申请公布日期 |
2012.05.30 |
| 申请号 |
ZA20090008477 |
申请日期 |
2009.11.30 |
| 申请人 |
MERCK SHARP & DOHME CORP |
发明人 |
COOPER ALAN;DENG YONGQI;SHIPPS JR GERALD W;SHIH NENG-YANG;ZHU HUGH;KELLY JOSEPH;DOLL RONALD J;NAN YANG;DESAI JAGDISH;WANG JAMES;PALIWAL SUNIL;TSUI HON-CHUNG;BOGA SOBHANA BABU;ALHASSAN ABDUL-BASIT;GAO XIAOLEI;ZHU LIANG;PATEL MEHUL P |
| 分类号 |
A61K;A61P;C07D |
主分类号 |
A61K |
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