Zero-order modified release solid dosage forms

摘要

The invention comprises a solid dosage form for delivery of water soluble pharmaceutical agents. The solid dosage form comprises a matrix core containg the pharmaceutical agent and a hydrophobic material; a modified release coating containing a hydrophilic pore-forming agent and a hydrophobic polymer; and an overcoating surrounding the modified release coating. The dosage form exhibits a zero-order release profile upon dissolution.