RECOMBINANT PSEUDOADENOVIRAL NANOPARTICLE, PHARMACEUTICAL COMPOSITION FOR INFLUENZA PROPHYLAXIS OR THERAPY (EMBODIMENTS), METHOD OF INFLUENZA PROPHYLAXES OR THERAPY

摘要

The present invention relates to a recombinant pseudoadenoviral nanoparticle carrying an expressing cassette containing a nucleotide sequence which encodes a single-domain mini-antibody associating with a influenza virus and applicable for influenza prophylaxis and therapy. Pharmaceutical compositions are provided both containing only the pseudoadenoviral nanoparticles and containing additionally encoded by them single-domain mini-antibodies against the influenza virus, for example, relating to a type A (and characterized by antigen formulae H1N(1-9), H3N(1-9) or H5N(1-9) or to a type B. The composition is preferably intranasal administered.