| 发明名称 |
3-amino-5-phenyl-5,6-dihydro-2H-[1,4]oxazines |
| 摘要 |
The present invention relates to 3-Amino-5-phenyl-5,6-dihydro-2H-[1,4]oxazines of formula I having BACE1 and/or BACE2 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease and type 2 diabetes.
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| 申请公布号 |
US8188079(B2) |
申请公布日期 |
2012.05.29 |
| 申请号 |
US20100852538 |
申请日期 |
2010.08.09 |
| 申请人 |
ANDREINI MATTEO;BANNER DAVID;GUBA WOLFGANG;HILPERT HANS;MAUSER HARALD;MAYWEG ALEXANDER V.;NARQUIZIAN ROBERT;POWER EOIN;ROGERS-EVANS MARK;TRAVAGLI MASSIMILIANO;VALACCHI MICHELA;WOLTERING THOMAS;WOSTL WOLFGANG;HOFFMAN-LA ROCHE INC.;SIENA BIOTECH S.P.A. |
发明人 |
ANDREINI MATTEO;BANNER DAVID;GUBA WOLFGANG;HILPERT HANS;MAUSER HARALD;MAYWEG ALEXANDER V.;NARQUIZIAN ROBERT;POWER EOIN;ROGERS-EVANS MARK;TRAVAGLI MASSIMILIANO;VALACCHI MICHELA;WOLTERING THOMAS;WOSTL WOLFGANG |
| 分类号 |
A61K31/535;C07D413/12 |
主分类号 |
A61K31/535 |
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