AN ANTIHISTAMINE ANTIALLERGIC AGENT AND A METHOD OF DERIVING IT

摘要

The invention relates to a range of original xanthine derivatives substituted in 1- and 7- positions with benzhydryl-4-piperazinyl-1-alkane fragments. (see formula I) (see formula II) A method for obtaining 3-methyl-7-[4-(benzhydryl-4-piperazinyl-1) butyl] xanthine and the salts thereof with organic and inorganic acids by alkylating the 7-potassium salt of 3-methylxanthine by 1,4-dibromobutane, by subsequently interacting the thus formed 7-(4-bromobutyl)-3--methylxanthine with 1-benzhydrylpiperazinyl and by neutralising the thus obtained radical 7-/4--(4-benzhydrylpiperazinyl-1) butyl/-3-methylxanthine by an organic or inorganic acid is also disclosed.