摘要 |
Compounds are provided which are useful as antidiabetic agents and antiobesity agents and have the structure (I) wherein m is 0, 1 or 2; n is 0, 1 or 2; Q is C or N; A is (CH~2)x where x is 1 to 5, or A is (CH~2)x1 where x1~ is 1 to 5 with an alkenyl bond or an alkynyl bond embedded anywhere in the chain, or A is -(CH~2)x2~-O-(CH~2)x3~- where x2~ is 0 to 5 and x3~ is 0 to 5, provided that at least one of x2~ and x3~ is other than 0; B is a bond or is (CH~2)x4~ where x4~ is 1 to 5; X is CH or N; X~2 is C, N, O or S; X~3 is C, N, O or S; X~4 is C, N, O or S; X~5 is C, N, O or S; X~6 is C, N, O or S; provided that at least one of X~2, X~3, X~4 X~5 and X~6 is N; and at least one of X~2, X~3, X~4, X~5 and X~6 is C, and specifically excluding the structure (II) where X~2 = N, X~3 = C, X~4 = O or S, Z = o or a bond; R1~ is H or alkyl; R2~ is H, alkyl, alkoxy, halogen, amino or substituted amino or cyano; R2a~, R2b~ and R2c~ may be the same or different and are selected from H, alkyl, alkoxy, halogen, amino or substituted amino or cyano; and R3~ and Y are as defined herein, which compounds are useful in treating diabetes and obesity.
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