发明名称 |
NOVEL HETEROCYCLES AS INHIBITORS OF LEUCOCYTE ADHESION AND AS VLA-4 ANTAGONISTS |
摘要 |
The present invention relates to compounds of the formula I (see formula I) which are inhibitors of the adhesion and migration of leucocytes and/or antagonists of the adhesion receptor VLA-4 which belongs to the group of integrins. The invention also relates to processes for their preparation, to the use of compounds of the formula I for the treatment or prophylaxis of diseases which are caused by an undesired extent of leucocyte adhesion and/or leucocyte migration or which are associated therewith or in which cell-cell or cell-matrix interactions which are based on interactions of VLA-4 receptors with their ligands play a part, for example of inflammatory processes, of rheumatoid arthritis or of allergic disorders, and also to the use of compounds of the formula I for the production of pharmaceuticals for use in such diseases, and to pharmaceutical preparations which contain the compounds of the formula I.
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申请公布号 |
CA2220777(C) |
申请公布日期 |
2012.05.29 |
申请号 |
CA19972220777 |
申请日期 |
1997.11.12 |
申请人 |
HOECHST AKTIENGESELLSCHAFT |
发明人 |
STILZ, HANS ULRICH;WEHNER, VOLKMAR;HULS, CHRISTOPH;SEIFFGE, DIRK |
分类号 |
C07D277/20;C07K5/072;A61K31/415;A61K38/00;A61K38/05;A61K38/06;A61K38/07;A61P3/08;A61P9/00;A61P9/10;A61P11/00;A61P11/06;A61P19/02;A61P29/00;A61P33/02;A61P35/00;A61P37/00;A61P37/08;A61P43/00;C07D233/54;C07D233/72;C07D233/76;C07D277/34;C07K5/06;C07K5/078;C07K5/097;C07K5/107;C07K5/11;C07K5/117 |
主分类号 |
C07D277/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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