摘要 |
Disclosed are four compounds: 5-{ 3-Fluoro-4-[(5S)-2-(cis-4-hydroxycyclohexyl)-1-oxo-2,7-diazaspiro[4.5]dec-7-yl]phenyl} -N,N-dimethylpyridine-2-carboxamide; 5-{ 3-Fluoro-4-[(5S)-2-(cis-4-hydroxycyclohexyl)-1-oxo-2,7-diazaspiro[4.5]dec-7-yl]phenyl} -N-methylpyridine-2-carboxamide; N-Ethyl-5-{ 3-fluoro-4-[(5S)-2-(cis-4-hydroxycyclohexyl)-1-oxo-2,7-diazaspiro[4.5]dec-7-yl]phenyl} pyridine-2-carboxamide; 5-{ 3-Chloro-4-[(5S)-2-(cis-4-hydroxycyclohexyl)-1-oxo-2,7-diazaspiro[4.5]dec-7-yl]phenyl} -N-ethylpyridine-2-carboxamide; and pharmaceutically acceptable salts thereof. The compounds are useful for: inhibiting activity of 11bHSD, the conversion of cortisone to cortisol in a cell, inhibiting the production of cortisol in a cell, and for treating obesity, diabetes, glucose intolerance, insulin resistance, hyperglycaemia (hyperglycemia), hypertension, hyperlipidaemia (hyperlipidemia), cognitive impairment, depression, dementia, glaucoma, cardiovascular disorders, osteoporosis, inflammation, metabolic syndrome, androgen excess; or polycystic ovary syndrome (PCOS). |