cMET INHIBITORS

摘要

Disclosed are imidazo pyridazinyl c-MET inhibitor compounds of formula I, salts thereof, and methods for their preparation. Specific examples of compounds of formula I include N-(6-([1,2,4]triazolo[4,3-a]pyridin-3-ylthio)imidazo[1,2-b ]pyridazin-2-yl)cyclopropanecarboxamide; Cyclopropanecarboxylic acid [6-(6-bromo-benzotriazol-1-ylmethyl)-imidazo[1,2-b]pyridazin-2-yl]-amide; N-(6-(6-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridin-3-ylthio)imidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide; N-(6-(6-(6-methoxypyridin-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-ylthio)imidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide; Also disclosed are methods for inhibiting cMET using the compounds of formula I