HETEROARYLS AMIDE DERIVATIVES AND THEIR USE AS GLUCOKINASE ACTIVATORS

摘要

Disclosed are substituted heteroaryl compounds of formula (1A), or a pharmaceutically acceptable salt thereof, wherein the substituents are as described within the specification. Examples of compounds of formula (1A) include: (S)-3-cyclopentyl-2-(4-(isopropylsulfonyl)-1H-imidazol-1-yl)-N-(5-methylpyridin-2-yl)propanamide; and (S)-6-(3-cyclopentyl-2-(4-(methylsulfonyl)-1H-imidazol-1-yl)propanamido)nicotinic acid. Further disclosed is a pharmaceutical composition comprising a therapeutically effective amount of a compound of formula (1A), and the use of a compound of formula (1A) in the manufacture of a medicament for treating or delaying the progression of diabetes and/or diabetes-related disorders.