发明名称 |
NOVEL POLYMER DERIVATIVE OF CYTIDINE METABOLIC ANTAGONIST |
摘要 |
[Problem] To provide a novel polymer derivative of a cytidine metabolism antagonist with which drug release is possible independent of a biological enzyme and with which a highly therapeutic effect is expected. [Solution] A polymer derivative of a cytidine metabolism antagonist in which substituent groups represented by general formula (I) or general formula (II) [where R7 and R8 are each independently a hydrogen atom or C1-6 alkyl group optionally having substituent groups; R6 is a hydrogen atom, C1-40 alkyl group optionally having substituent groups, C1-40 aralkyl group optionally having substituent groups, aromatic group optionally having substituent groups, amino acid residue protected by carboxy groups, or sugar residue optionally having substituent groups; CX-CY is CH-CH or C=C (double bond); and A is a residue in which the amino group at position 4 has been removed from the cytidine metabolism antagonist] are bonded to the side chain carboxy groups of a block copolymer formed by a polyethylene glycol structural segment and a polymer having ten or more carboxy groups. |
申请公布号 |
CA2816997(A1) |
申请公布日期 |
2012.05.24 |
申请号 |
CA20112816997 |
申请日期 |
2011.11.16 |
申请人 |
NIPPON KAYAKU KABUSHIKI KAISHA |
发明人 |
YAMAMOTO, KEIICHIROU;OKAZAKI, MANAMI;KAWAMURA, DAI |
分类号 |
A61K31/7068;A61K9/107;A61K47/48;A61P31/12;A61P35/00 |
主分类号 |
A61K31/7068 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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