摘要 |
The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of CTNNB1 gene expression and/or activity, and/or modulate a beta-catenin gene expression pathway. Specifically, the invention relates to double-stranded nucleic acid molecules including small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules that are capable of mediating or that mediate RNA interference (RNAi) against CTNNB1 gene expression. |
申请人 |
MERCK SHARP & DOHME CORP.;BROWN, DUNCAN;CUNNINGHAM, JAMES, J.;GINDY, MARIAN;PICKERING, VICTORIA;STANTON, MATTHEW, G.;STIRDIVANT, STEVEN, M.;STRAPPS, WALTER |
发明人 |
BROWN, DUNCAN;CUNNINGHAM, JAMES, J.;GINDY, MARIAN;PICKERING, VICTORIA;STANTON, MATTHEW, G.;STIRDIVANT, STEVEN, M.;STRAPPS, WALTER |