发明名称 METHOD FOR PRODUCING COMPOUND FOR PREVENTING AND/OR TREATING THROMBUS EMBOLIC DISORDER
摘要 <P>PROBLEM TO BE SOLVED: To provide a method for producing a compound that functions as an inhibitor of a coagulation factor and is used for preventing and/or treating thrombus embolic disorders, particularly such as myocardial infarction, angina pectoris, peripheral arterial embolic disease, pulmonary embolism and deep-vein thrombosis. <P>SOLUTION: In reacting a 4-ä4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one(VII) hydrochloride with 5-chlorothiophene-2-carbonyl chloride(IV) to produce 5-chloro-N-(ä(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-2-thiophenecarboxamide represented by formula (I), the reaction is conducted using an inorganic base in a solvent selected from the group consisting of ethers, alcohols, ketones and water, or in a mixture thereof. <P>COPYRIGHT: (C)2012,JPO&INPIT
申请公布号 JP2012097106(A) 申请公布日期 2012.05.24
申请号 JP20110286538 申请日期 2011.12.27
申请人 BAYER PHARMA AG 发明人 BERWE MATHIAS;THOMAS CHRISTIAN;REHSE JOACHIM;GROTJOHANN DIRK
分类号 C07D413/14;A61K31/5377;A61P7/02;A61P9/10;C07D409/14;C07D413/12 主分类号 C07D413/14
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