摘要 |
<P>PROBLEM TO BE SOLVED: To provide a method for producing a compound that functions as an inhibitor of a coagulation factor and is used for preventing and/or treating thrombus embolic disorders, particularly such as myocardial infarction, angina pectoris, peripheral arterial embolic disease, pulmonary embolism and deep-vein thrombosis. <P>SOLUTION: In reacting a 4-ä4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one(VII) hydrochloride with 5-chlorothiophene-2-carbonyl chloride(IV) to produce 5-chloro-N-(ä(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-2-thiophenecarboxamide represented by formula (I), the reaction is conducted using an inorganic base in a solvent selected from the group consisting of ethers, alcohols, ketones and water, or in a mixture thereof. <P>COPYRIGHT: (C)2012,JPO&INPIT |